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Established since 1951, we provide a full range of services as a CDMO for Live biotherapeutic products (LPB).

Contact us

+33 4 71 46 80 00

info@biose.com

24 Avenue Georges Pompidou, 15000 Aurillac, France

Mon - Frid, 8 AM - 5 PM

Closed on Saturday - Sunday.

GMP Industrial Scale Up

The 20-liter fermenter, which is the last step in our lab development, is a perfectly scaled copy of industrial fermenters and allows for a seamless transfer to industrial scale.

The scale-up unit is integrated in a full GMP suite and encloses the following materials, all including Cleaning in Place (CIP) and Sterilization in Place (SIP):

  • Fermenter with working volume from 100 to 300 liters
  • Plate centrifugation
  • Cryoprotectant mixing tank
  • Freeze drying unit
  • Grinding
  • Bulk powder packaging in pouches, vacuum sealed.

Executing scale up in an industrial GMP suite allows biose industrie to validate in process controls, industrial yields and cleaning methods.