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Established since 1951, we provide a full range of services as a CDMO for Live biotherapeutic products (LPB).

Contact us

+33 4 71 46 80 00

info@biose.com

24 Avenue Georges Pompidou, 15000 Aurillac, France

Mon - Frid, 8 AM - 5 PM

Closed on Saturday - Sunday.

How we make LPB’s

We’ve been manufacturating LBP’s since 1951.

To develop and manufacture an LBP :

you first need to isolate and identify a specific single strain or multi strain combination.

From their it’s necessary to characterize the strain using in vitro methods to understand it’s resistance biological substance, sensitivity to antibiotics etc… .

From there we develop the manufacturing process

  •     Culture media and conditions (fermenters from 0.5 to 20 liters working volume)
  •     Concentration/purification
  •     Cryoprotectants
  •     Freeze-drying cycles (freeze-drying capacity from 0.5 to 4 m²)
  •     Grinding / milling development
  •     Stabilities optimization

Dosage form development

  •     Tablets, with specific technology to avoid damaging the bacteria during compression
  •     Powders
  •     Capsules
  •     Liquides