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Established since 1951, we provide a full range of services as a CDMO for Live biotherapeutic products (LPB).

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+33 4 71 46 80 00

info@biose.com

24 Avenue Georges Pompidou, 15000 Aurillac, France

Mon - Frid, 8 AM - 5 PM

Closed on Saturday - Sunday.

Nature, function and location

The Microbiome is often referred to as the forgotten organ and can weigh anything from 1 to 3 kg which is effectively as much if not more than the human brain. The most active and diverse area of the Human Microbiome is of course the gut microbiota where there is not only a non-harmful coexistence but also a mutualistic or symbiotic relationship. The human gut has up to and maybe exceeding 1000 bacterial species that encode in excess of 5 million genes.

In addition to the gut, bacteria are present on human tissue and biofluids such as the skin, lungs, oral & nasal cavities and the vagina, recent screening techniques have allowed us to detect and isolate species in what where previously perceived to be sterile environments such as the brain, urinary tract, the uterus and the biliary tract.

The first three years of life see frequent changes in the Microbiome. It has long been assumed that we are first introduced to microbes via the mother’s birth canal which is saidto have a major influence on the future microbiome of an individual – it’s also important to know that children delivered by C-section have reduced bacterial diversity compared to children from natural births. However recent studies have also shown that there is some evidence of bacterial presence in the placenta and even in amniotic fluid.

What is certain is that the microbiome becomes stable at around 3 years old. This stability is not static and there are microbial changes happening all the time which we still do not fully understand which are influenced by many different factors such as diet, gender, lifestyle and habitat. More recent findings have shown that medication can also have an important effect on our Microbiome

Human Microbiome: why is it important for Health?

The Microbiome is active in the digestion of our food and hence nutrition, it also influences our immune system via the production of a host of different metabolites which have an enormous influence, generally vital and positive, on our health. However, when our microbiome is in Dysbiosis (microbial imbalance due to the reduction in presence of beneficial bacteria being outcompeted by non-benefical or even pathogenic bacteria) it can lead to complications and chronic diseases which can lead to serious conditions such as diabetes or heart and liver problems!

“Unique to each of us, it comprises a population of thousands of microorganisms, living harmoniously with our body, which shelters them. Resilient by nature, this microbiota is constantly seeking its equilibrium. It plays a major defensive role by strengthening the mucous membranes and interacting with our immune system.”